Epinephrine infusions, during antiarrhythmic drug evaluations: Toward a better understanding of drug activity
نویسندگان
چکیده
منابع مشابه
The antiarrhythmic drug BRL-32872.
BRL-32872 is a new antiarrhythmic drug with balanced class-III and class-IV actions as categorized by the Vaughan-Williams classification. BRL-32872 blocks the rapid component of the cardiac delayed rectifier potassium channel IK(r) (IC(50) = 28 nM) and its molecular correlate HERG ("Human-ether-a-go-go related gene," IC(50) of 19.8 nM in cell lines) at low concentrations. It also inhibits the ...
متن کاملLidoflazine as an antiarrhythmic drug.
Since Schaper and his coworkers1-3 reported an excellent coronary vasodilating action of lidofiazine, a drug originally prepared in Janssen Pharmaceutica Institute, on conscious dogs with a previously implanted electromagnetic flow meter, the antianginal effect of the drug has been clinically investigated in our own and other laboratories. Its usual dose is 90 or 120mg per day. Recently, we adm...
متن کاملToward a Better Understanding of Leaderboard
The leaderboard in machine learning competitions is a tool to show the performance of various participants and to compare them. However, the leaderboard quickly becomes no longer accurate, due to hack or overfitting. This article gives two advices to avoid this. It also points out that the Ladder leaderboard successfully prevents this with Õ( −3) samples in the validation set.
متن کاملToward a better understanding of RRAM
Abstract The origin of switching parameter variations in metal-oxide resistive-switching random access memory (RRAM) is studied. The stochastic formation/rupture of the conductive filaments (CFs) is modeled and incorporated with a trap-assisted-tunneling (TAT) current solver. The experimental DC I-V characteristics and pulse transient waveform featuring the current fluctuation during the reset ...
متن کاملAntiarrhythmic drug treatment: need for continuous vigilance.
Any physician treating cardiac arrhythmias should be aware of a possible worsening of the arrhythmia (so-called arrhythmogenesis) after the start of antiarrhythmic drug treatment. To facilitate the recognition of that complication the type and possible mechanisms of arrhythmogenesis are reviewed. Recognition also requires an understanding of (a) the time of appearance of arrhythmogenic effects ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1992
ISSN: 0735-1097
DOI: 10.1016/0735-1097(92)90491-5